Anti-Age Pack

Astragaloside IV is an anti-ageing supplement in vegetarian capsules with several beneficial properties, particularly immunostimulant, anti-inflammatory, antioxidant and anti-glycation. Its exceptional properties are due to astragaloside's specific ability to activate telomerase, thus slowing down the shortening of telomeres, and extending cell lifespan. Shortening of telomeres is associated with cellular ageing and the development of age-related diseases.

How is Astragaloside IV obtained?

Astragaloside IV is present in minute amounts in the root of Astragalus (Astragalus membranaceus), a plant particularly valued in traditional Chinese medicine. Through a highly complex and expensive process, it is extracted and concentrated in order to obtain an active amount. Commercially available products sold in the form of powder or astragalus extract do not contain detectable amounts of Astragaloside IV. Astragalus root has been prescribed for centuries as a tonic, as well as to treat a wide range of diseases, to prevent weakness in patients and to protect them against infection.

What are the benefits associated with Astragaloside IV capsules?

Astragalus root contains, amongst others, a series of cycloartane glycosides called astragalosides I to VII. The most widely studied of these, in Chinese and European research centres, is astragaloside IV. Studies suggest, amongst others, that astragalus root extract and astragaloside IV have the following properties:

• Immunostimulant: acting through a number of different pathways, especially by increasing the number of stem cells in the spinal cord and lymphatic tissue and encouraging them to develop into active immune cells and by stimulating the production of immunoglobulins and macrophages;
• Anti-inflammatory: as shown in certain animal models. The ability of astragaloside IV to stem inflammation of the airways in chronic asthma has been reported in studies on mice.
• Antibacterial: as demonstrated by in vitro studies on Shigella dysenteriae, Streptococcus haemolyticus, Diplococcus pneumoniae and Staphylococcus aureus.
• Antiviral: inhibiting replication of certain viruses such as coxsackie, responsible for myocarditis (inflammation of the heart muscle). In both animal and human studies, they were shown to stimulate endogenous interferon production and to maximise its effect on viral infections.
• Antioxidant: inhibiting lipid peroxidation by 40% in vitro. These antioxidant properties may go some way to explaining the cardio- and neuroprotective effects of astragalus and astragaloside IV.
• Cardioprotective: with studies highlighting health benefits for patients with congestive cardiac insufficiency and angina pectoris. Astragalus extracts have a cardiotonic effect.
• Neuroprotective: in traditional Chinese medicine, astragalus root extract is used to treat neurodegenerative diseases. One study demonstrated the capacity of astragaloside IV to protect dopaminergic neurons (progressive degeneration of dopaminergic neurons leads to the development of Parkinson's disease).

Telomere shortening is currently one of the most widely studied areas of anti-ageing medicine. Along with astragaloside IV, there's a number of natural active principles available to buy at Supersmart, that have been identified for their ability to protect telomeres or stimulate telomerase. Two such ingredients are cycloastragenol and resveratrol. Other beneficial compounds, such as vitamins C and E, carnosine and several natural antioxidants, have also been included in the enhanced formulation Telomeres Maintenance Formula. The shortest telomeres have been observed in octogenarians. Research also suggests that individuals aged 60 or older with the shortest telomers appear to be at significantly higher risk of death from infectious disease or heart attacks. Conversely, studies have shown that stimulating telomerase may significantly increase cell lifespan.

Buy Astragaloside IV to fight cellular ageing.

Adults. Take 1 to 2 capsules a day.
Each capsule contains 50 mg astragaloside IV.

Advice on taking Astragaloside IV and Resveratrol Synergy
We do not yet have enough evidence to recommend taking Astragaloside IV and Resveratrol Synergy together, every day, for prolonged periods.
At the moment, some people take Astragaloside IV in the morning (two capsules) then one capsule of Resveratrol Synergy at lunchtime and one in the evening. Others alternate the two products: one on one day, the other the next day; one, for one week, the other for the following week; or one for one month and the other for the next month.
Some people take a break every month and some every three months, others do not. Choose the option that suits you best and gives you the most benefits. There have been no reports so far of intolerance to these products.

Cycloastragenol 98% is an astragalus supplement standardised to 98% cycloastragenol, a widely-studied molecule and an ideal candidate for the pharmacopeia of tomorrow. A tonic and adaptogen, it supports physical and mental well-being.

What is astragalus and what are its effects?

Astragalus is a perennial plant native to China which is part of the legume family. Its amazing nutritional composition is the reason why it is attracting so much scientific interest. It contains, in particular, (1-3):

• Good-quality flavonoids: astragalin, isoflavonoids (metabolised into daidzein), formononetin, ononin, calycosin…
• Remarkable saponosides: astragaloside (I to IV) and its more absorbable derivative, cycloastragenol.
• Interesting lineages and sterols: lariciresinol, syringaresinol, sitosterol, daucosterol…

Its effects, however, are primarily due to its high content of saponosides, particularly cycloastragenol. That’s why our supplement is standardised to 98% of this compound with highly-promising properties. The scientific literature has highlighted several distinct effects:

• its support for physical well-being;
• its tonic properties for mental health (4-5) ;
• its role in regenerating the skin;
• its role in maintaining normal blood pressure.

In traditional medicine, it has been used for thousands of years by Hindus to “boost vital energy and increase the body’s resistance”.

Who is Cycloastragenol 98% aimed at?

Cycloastragenol 98% – taken either as a course or over more prolonged periods – is targeted at anyone over 40, particularly those keen to stay in good shape physically and mentally as they age.

Are there any contraindications for taking Cycloastragenol 98%?

Because of its properties, astragalus should be used with caution by those receiving immune-suppressant therapy. It is not recommended for anyone allergic to plants from the Fabaceae family, or for women who are pregnant or breastfeeding.

No other contraindications have been reported (6).

Synergistic supplements to take alongside Cycloastragenol 98%

In parallel with your course of Cycloastragenol 98%, we’d recommend considering the following supplements :

• Astragaloside IV, also from astragalus, to cover a wider spectrum of the plant’s activity, or to alternate with Cycloastragenol 98%. As yet, there is insufficient data to be able to recommend taking both these products together, every day, for prolonged periods. However, no intolerance has been reported so far.
• Senolytic Complex, a revolutionary formulation with a high content of fisetin, the most powerful natural senolytic compound ever identified, and of phytosomal quercetin, 20 times more absorbable than standard quercetin. This best-selling product is based on the most recent research in the field of senotherapy.

You can also opt for the more potent version of this supplement, CycloAstragenol Maximum Strength 98%, with a rarely available, 2.5 times higher dose which, though more expensive, offers even greater efficacy.

Anti-ageing tips to restrict the rate of senescence

It is not yet possible to push back the ageing process indefinitely but there are ways of containing it. Science has identified a number of the biological mechanisms involved (oxidative stress, DNA damage, shortening of telomeres, inflammation ...). To give yourself the best possible chance of staying young for as long as possible, we recommend adopting the following measures alongside supplementing with Cycloastragenol 98%:

• Make sure you get as many antioxidants as possible from your diet. Generally-speaking, highly-coloured foods contain the most, so eat as many fruits and vegetables as you want.
• Take regular exercise. Moderately-intense physical activity helps to fight against ageing and its associated diseases.
• Take time to breathe. Stress is known to accelerate ageing, particularly ageing of the brain.
• Drink plenty of water. Cellular imbalance caused by dehydration can increase the long-term risk of age-related diseases. Don’t wait until you’re thirsty to reach for that glass of water: drink regularly, at least a litre and a half of fluid a day – more if you’re physically active.
• Stimulate your brain. Mental exercises (maths, memory or logic puzzles ...) have been shown to reduce age-related loss of cognitive ability.

Daily dose : 2 capsules Number of doses per pack : 15	Amount per dose
Cycloastragenol 98%	20 mg
Other ingredients : Acacia gum, rice flour.

Adults.
Take one or two capsules a day, or as advised by your therapist. Each capsule contains 10 mg of cycloastragenol.