Mitochondrial Formula Supplement - Antioxidant Protection for Mitochondria

Mitochondrial Formula is an exceptional formulation in vegetarian capsules combining three essential anti-ageing compounds: pyrroloquinoline quinone (PQQ), R alpha-lipoic acid and acetyl-L-carnitine.

It is one of the best products on the market along with Astragaloside IV.

Who is Mitochondrial Formula aimed at?

Mitochondrial Formula is for anyone over 50 who wants to age well. It has been formulated to optimise existing mitochondrial function and facilitate the biogenesis of new mitochondria.

What are the benefits associated with Mitochondrial Formula?

Mitochondrial Formula contains three exceptional compounds that benefit the antioxidant system and mitochondrial function.

Pyrroloquinoline quinone (PQQ) (10mg per capsule).

PQQ is a ‘gold-standard’ antioxidant found in very small amounts in the diet and in the metabolic products of certain gut bacteria. Laboratory studies have shown (1-3) it has a positive effect on mitochondrial function, and thus plays a major role in controlling the ageing process and protecting nerve cells. Unlike other micronutrients that improve the function of existing mitochondria, PQQ also helps to increase their numbers. This is a significant advantage as we know that mitochondria numbers decline with age…

Alpha-lipoic acid (the R form).

Produced naturally by the body and present in small amounts in leafy vegetables, this is, without doubt, the most effective endogenous antioxidant. This is because of four exceptional properties (4-6):

• Its versatility: it attacks oxidants in both aqueous and lipid environments, unlike vitamin E (lipid only) and vitamin C (aqueous only).
• Its regenerative power: it is able to recycle ‘used’ antioxidants that have been neutralised by oxidative elements, and so increases the life and efficacy of vitamins E and C and glutathione (it also promotes the production of the latter).
• Its chelating effect: it can trap heavy metals such as arsenic, cadmium and mercury.
• Its ability to repair: in certain cases, it is able to repair oxidative damage to molecules, particularly proteins.

Acetyl-L-carnitine (250mg per capsule)

Carnitine is an amino acid used by the body to convert fats into energy (in the form of ATP). The body produces it from lysine and methionine, two simpler amino acids found abundantly in food.

But this process, which also requires vitamin C, several enzymes, iron, vitamin B6 and vitamin B3, appears to ‘peter out’ as we get older. It’s not known whether these are the kind of frequently-observed declines that are related to age or whether it’s the ageing process itself which upsets the production mechanism, but the fact is that energy-demanding cells such as those of the heart muscles and brain, end up short of ‘fuel’.

Why is it important to take care of our mitochondria?

Mitochondria are the little powerhouses found in each of our cells which convert the energy in our food into a form that can be used by the body (‘ATP’). Over time, these powerhouses become compromised because this energy conversion involves the unwelcome production of toxic molecules called reactive oxygen species (ROS). While these unstable molecules attack the body as a whole, they have a preference for compounds close to their site of production. Mitochondria are therefore particularly affected by oxidative attack throughout life.

The body fights off these attacks by producing antioxidants, which, rather like a ‘flak-jacket’, take the brunt of these attacks in the place of molecules that are important to the body order for it to function properly. It also uses exogenous antioxidants obtained from the diet or produced by the bacteria with which it collaborates. PQQ is one of these exogenous antioxidants. It’s found in tiny amounts in plant-sourced foods, primarily green vegetables (7).

Over time, the damage from these attacks degrades the systems responsible for producing endogenous antioxidants, which rapidly increases the extent of the damage and speeds up the overall decline. It is precisely to delay this latter stage that antioxidant supplements have been developed such as lipoic acid and PQQ. This offers the additional benefit of supporting the growth of new mitochondria (8-9).

As these powerhouses ensure the conversion of energy essential for life, mitochondrial dysfunction quickly leads to accelerated ageing and a deterioration in health.

When should Mitochondrial Formula be taken?

There are two things to bear in mind here:

• PQQ and carnitine are absorbed most effectively when taken with fat-containing food (as they’re fat-soluble).
• R alpha-lipoic acid has a relatively short life in the body so it’s better to take two capsules at different times of the day.

It’s therefore advisable to take one capsule in the morning with breakfast (ensuring it contains some fat), and potentially a second capsule with lunch.

In clinical studies, scientists used doses of 10mcg-20mcg of PQQ a day. In studies demonstrating benefits from supplementation with alpha-lipoic acid and PQQ, several weeks’ treatment was required before these effects were seen.

Four good reasons to choose Mitochondrial Formula

1. It contains the R form of alpha-lipoic acid, the form produced by the body.
2. Alpha-lipoic acid supplements are always produced in a laboratory. The process results in a mix of two forms: the R and S forms. The R form is exactly the same molecule as that produced by our bodies, while the S form is merely a poor copy and appears to be completely inactive once absorbed. Most of the supplements on the market contain both forms as separating them is quite a costly process. Mitochondrial Formula contains just the R form, avoiding the need to ingest the non-natural and inactive S form.
3. The form of carnitine included is fat-soluble, which means it acts more specifically in the brain (10-15). The majority of carnitine supplements contain water-soluble forms.
4. Older people’s cells contain far fewer mitochondria than those of young people, and function slowly. This leads to a significant fall in energy production. This is a factor in almost all age-related degenerative diseases.
5. Mitochondria have their own DNA which unlike the DNA in the cell nucleus, does not have effective repair systems. They are therefore much more vulnerable to self-generated ROS.

Buy Mitochondrial Formula to support mitochondrial function.

Can other supplements be taken alongside Mitochondrial Formula?

Yes, it’s perfectly possible to combine Mitochondrial Formula with a number of other products available to buy at Supersmart. In addition to the previously mentioned anti-ageing supplements, you can also take:

• Stem Cells Activator, an enhanced formulation for increasing the capacity for cell division.
• AC-11®, a patented extract of Cat’s Claw (Uncaria tomentosa).
• AMPK Booster, for countering metabolic decline.
• Asc2P, a powerful form of vitamin C for boosting the antioxidant system.
• the exceptional Anti-Aging Pack for slowing down the ageing process.

Mitochondrial Formula: contraindications and storage

Carnitine is not recommended for anyone with hypothyroidism as it has a mild effect on the action of the thyroid hormone (16).

Since alpha-lipoic acid is very sensitive to heat, humidity and light, Mitochondrial Formula must be kept in a cool, dry place, away from light.

Notes

This product should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. It’s important to follow the guidelines on how to take it and the recommended dose, and to use it by the ‘best before’ date. It is not recommended for women who are pregnant or breastfeeding, or for children under 15. Keep out of children’s reach. Store in a cool, dry place

Updated: 30/01/2018

1. Masahiko Nakano et al. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep, Functional Foods in Health and Disease 2012, 2(8):307-324
2. Meléndez-Illanes, L., González-Díaz, C., Chilet-Rosell, E., & Álvarez-Dardet, C. (2015). Does the scientific evidence support the advertising claims made for products containingLactobacillus caseiandBifidobacterium lactis? A systematic review. Journal of Public Health, 38(3), e375–e383. doi:10.1093/pubmed/fdv151
3. Min, Z., Wang, L., Jin, J., Wang, X., Zhu, B., Chen, H., & Cheng, Y. (2014). Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression. Journal of Cancer, 5(7), 609–624. doi:10.7150/jca.9002
4. Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. General pharmacology. 1997;29(3):315-31. Epub 1997/09/01
5. Goraca A, Huk-Kolega H, Piechota A, Kleniewska P, Ciejka E, Skibska B. Lipoic acid - biological activity and therapeutic potential. Pharmacological reports : PR. 2011;63(4):849-58. Epub 2011/10/18.
6. Packer L, Witt EH, Tritschler HJ. alpha-Lipoic acid as a biological antioxidant. Free radical biology & medicine. 1995;19(2):227-50. Epub 1995/08/01.
7. Kumazawa et al. Levels of PQQ in various foods, Research Communication, Biochem. J. (1995) 307, 331-333
8. Chowanadisai, W., Bauerly, K. A., Tchaparian, E., Wong, A., Cortopassi, G. A., & Rucker, R. B. (2009). Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression. Journal of Biological Chemistry, 285(1), 142–152. doi:10.1074/jbc.m109.030130
9. Min, Z., Wang, L., Jin, J., Wang, X., Zhu, B., Chen, H., & Cheng, Y. (2014). Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression. Journal of Cancer, 5(7), 609–624. doi:10.7150/jca.9002
10. Passeri M, Cucinotta D, Bonati PA, et al. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Int J Clin Pharmacol Res. 1990;10:75-79.
11. Calvani M, Carta A, Caruso G, et al. Action of acetyl-L-carnitine in neurodegeneration and Alzheimer's disease. Ann N Y Acad Sci. 1992;663:483-486.
12. Sano M, Bell K, Cote L, et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's disease. Arch Neurol. 1992;49:1137-1141.
13. Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology. 1991;41:1726-1732.
14. Campi N, Todeschini GP, Scarzella L. Selegiline versus L-acetylcarnitine in the treatment of Alzheimer-type dementia. Clin Ther. 1990;12:306-314.
15. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol. 2003;18:61-71
16. Benvenga S, Lakshmanan M, Trimarchi F. Carnitine is a naturally occurring inhibitor of thyroid hormone nuclear uptake. Thyroid. 2000;10:1043-1050.